Pall Ultipor VF virus removal filter cartridges feature innovative hydrophilic PVDF microporous membranes to remove significant levels of viruses from biological solutions, while enabling > 95% transmission of proteins up to 300 kD or larger. Using patented Ultipleat crescent-shaped pleated elements, the filters to incorporate 1.6 m2 (17.5 ft2) of filter area per 10 in. (254 mm) element in standard single open-ended (SOE) AB sanitary style cartridges. Ultipor VF cartridges achieve practical flows and pressure drops while effectively removing nanometer-size viral contaminants with high protein yields.
An optional sub-0.1 µm rated prefilter (Grade DVD) and Fluorodyne II filters enhance throughputs and employ the same PVDF membrane material for ease of validation. Typical applications include purification of BioPharmaceuticals, tissue and plasma derivatives, protein additives, culture media, diagnostic reagents, buffers and diluents.

Features and Benefits

 Sanitary direct flow cartridges
 6 log Titer Reduction (TR) for 50 nm viruses (DV50 grade)
 Robust size exclusion mechanism
 PVDF microporous membranes
 Narrow pore-size distribution
 Inherently water wettable
 Low binding for high protein yields
 Very low extractables
 Steamable in situ
 100% integrity-tested
 Individually serialized
 Manufactured for use in conformance with cGMP
 ISO 9000 Certified Quality System
 Pharmaceutical P optimized
 Certificate of Test provided
 Validation Guide available
 Discs and mini-cartridges (SBF Junior Style) available
Note: These filters are also available in Kleenpak Nova capsule format.

Quality and Bio-Safety Biological Tests

Integrity

 Every DV50 grade filter integrity tested during manufacture. Test correlated to viral (phage) retention.

Biological Tests

 Meets USP Biological Reactivity Test, in vivo, for Class VI-121 °C Plastics

Effluent Quality Tests*

 Meets Cleanliness per USP Particulates in Injectables
 Non-Fiber-Releasing
 Non-Pyrogenic per USP Bacterial

Endotoxins (< 0.25 EU/mL)

 Meets Total Organic Carbon and Conductivity per USP Purified Water; pH per Sterile Purified Water

Autoclave Resistance

 Lot samples multi-cycle autoclave challenged
* Per lot sample or rinse-flush aliquots.